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Kenneth Loi

Graduate student,
Doudna Lab,
UC Berkeley Biophysics

Decoding life's longest war.

Research.

Harnessing evolution's designs.

Selected works

Science2026Co-first authorA noncontiguous code for RNA-guided DNA recognition at the origin of CRISPR-CasVIPR · RNA-guided DNA recognition · phage defense

For a broader introduction

Carl Zimmer in The New York TimesIGI’s discovery story

Science2026Shown rotatingVIPR RNA-guided DNA recognition by noncontiguous geometric triplex formationVIPR structure · RNA-guided DNA recognition

Nature2025A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathwayimmune signaling · bacterial defense · toxin-antitoxin systems

Science2024Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleasesRNA-guided RNase · structural homology · Cas13 ancestry

Nucleic Acids Research2023Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymestransposons · RNA-guided endonuclease

About.

Grew up on Frank Herbert, Ted Chiang, and my grandmother's gong sik chaau min under the Southern California Sun.

Probably somewhere flipping rocks.