Research.
Harnessing evolution's designs.
Selected works
Preprint2026Co-first authorA Noncontiguous Code for RNA-Guided DNA Recognition Preceded CRISPRVIPR · RNA-guided DNA recognition · phage defensePreprint2026Triplex formation drives noncontiguous VIPR RNA-guided DNA recognitionVIPR structure · RNA-guided DNA recognitionNature2025A miniature CRISPR-Cas10 enzyme confers immunity by an inverse signaling pathwayimmune signaling · bacterial defense · toxin-antitoxin systemsScience2024Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleasesRNA-guided RNase · structural homology · Cas13 ancestryNucleic Acids Research2023Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymestransposons · RNA-guided endonuclease
About.
Southern California kid.
Grew up on Frank Herbert, Ted Chiang, and my grandmother's gong sik chaau min.
Most of my thinking still happens somewhere in the space between those three.